Mednick S A, Parnas J, Schulsinger F
Schizophr Bull. 1987;13(3):485-95. doi: 10.1093/schbul/13.3.485.
Since 1962 we have followed a sample of 207 children at high risk for schizophrenia as well as 104 control children. For these individuals, the following factors and their interaction are related to an increased risk for schizophrenic breakdown: (1) greater schizophrenia family backgrounds, (2) perinatal trauma, and (3) unstable parenting and public institutional child care. The perinatal difficulties are positively related to adult periventricular atrophy. Results of a subsequent study tentatively suggest that part of the neurological deviance in schizophrenia may be produced by disruption occurring in the second trimester of fetal development.
自1962年以来，我们对207名精神分裂症高危儿童以及104名对照儿童进行了跟踪研究。对于这些个体，以下因素及其相互作用与精神分裂症发作风险增加有关：（1）更明显的精神分裂症家族背景，（2）围产期创伤，以及（3）不稳定的养育方式和公共机构的儿童照料。围产期困难与成人脑室周围萎缩呈正相关。后续研究结果初步表明，精神分裂症的部分神经偏差可能是由胎儿发育中期发生的干扰所致。
