Escourrou J, Ebeid A M, Fischer J E
Am J Surg. 1980 Jun;139(6):824-8. doi: 10.1016/0002-9610(80)90390-6.
The possible role of vasoactive intestinal peptide as an inhibitor of stimulated gastric secretion was investigated. Awake dogs with Heidenhain pouches were stimulated with pentagastrin alone and in combination with intraduodenal instillation of various potential inhibitors of gastrointestinal secretion including isotonic phenylalanine, 3 percent hypertonic saline solution and 0.16 normal hydrochloric acid. Plasma vasoactive intestinal peptide is significantly increased by pentagastrin, and this release is enhanced by intraduodenal hydrochloric acid. Simultaneously, there is significant inhibition of pentagastrin-stimulated Heidenhain pouch secretion. These findings provide evidence for a possible physiologic role of vasoactive intestinal peptide as an inhibitor of gastric secretion, at least in dogs.
研究了血管活性肠肽作为刺激胃酸分泌抑制剂的可能作用。对带有海登海因小胃的清醒犬，单独用五肽胃泌素刺激，以及与十二指肠内滴注各种潜在的胃肠分泌抑制剂（包括等渗苯丙氨酸、3%高渗盐溶液和0.16当量盐酸）联合刺激。五肽胃泌素可使血浆血管活性肠肽显著增加，十二指肠内盐酸可增强这种释放。同时，五肽胃泌素刺激的海登海因小胃分泌受到显著抑制。这些发现为血管活性肠肽作为胃酸分泌抑制剂的可能生理作用提供了证据，至少在犬类中是如此。
