Augmentation of luteinizing hormone action by prostaglandin E2 in the prevention of antispermatogenic effect of indomethacin. Indomethacin & spermatogenesis.

Administration of indomethacin exhibited antigonadal action by inhibiting the Leydig cells, sex-accessories and spermatocyte-spermatid conversion process. Administration of PGE2 or PGF2 alpha had no effect on Leydig cell nuclear volume or accessory organ weights, but PGE2 had a restorative effect on the efficiency of meiosis, although at a statistical non-significant level. Administration of LH to indomethacin treated rats restored the accessories fully with a non-significant effect on the yield of step-7 spermatids from meiosis. Simultaneous administration of indomethacin, LH and PGE2 (but not PGF2 alpha) restored both sex-accessories and spermatid number to the level of vehicle injected controls.