阿司匹林的抗生精作用及其被前列腺素E2的预防作用
Antispermatogenic effect of aspirin and its prevention by prostaglandin E2.
作者信息
Biswas N M, Sanyal S, Patra P B
出版信息
Andrologia. 1978 Mar-Apr;10(2):137-41. doi: 10.1111/j.1439-0272.1978.tb01328.x.
Abstract
Aspirin treatment causes a decrease in Leydig cell function, change in Sertoli cell morphology and a subsequent decrease in Spermatid count. Administration of Prostaglandin E2 prevents the effect of Aspirin on the Sertoli cell morphology and Spermatid degeneration without significant improvement of the Leydig cell function. On the basis of these findings, a possible relationship between Prostaglandin and testicular spermatogenesis has been discussed.
摘要
阿司匹林治疗会导致睾丸间质细胞功能下降、支持细胞形态改变以及随后的精子细胞数量减少。前列腺素E2的给药可预防阿司匹林对支持细胞形态和精子细胞变性的影响，但睾丸间质细胞功能无显著改善。基于这些发现，已讨论了前列腺素与睾丸精子发生之间可能的关系。
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