Baker T, Erker E F
Arch Int Pharmacodyn Ther. 1980 Jan;243(1):97-102.
The dose-response and time-action parameters for the prototype antiarrhythmic drugs lidocaine, propranolol and quinidine were established using a cardiac antiarrhythmic screening procedure in the rat. This simple screening procedure produces severe cardiac arrhythmias, primarily ventricular fibrillation, in young post-weaning rats which have been pretreated with a single intramuscular injection of theophylline (20 mg/kg) 15 to 45 min prior to their inhalation of chloroform vapors.
利用大鼠心脏抗心律失常筛选程序，确定了原型抗心律失常药物利多卡因、普萘洛尔和奎尼丁的剂量反应及时间作用参数。这种简单的筛选程序会在幼龄断奶后大鼠中引发严重心律失常，主要是心室颤动。这些大鼠在吸入氯仿蒸汽前15至45分钟，预先单次肌肉注射了氨茶碱（20毫克/千克）。
