Meltzer H Y, Ross-Stanton J, Schlessinger S
Arch Gen Psychiatry. 1980 Jun;37(6):650-5. doi: 10.1001/archpsyc.1980.01780190048006.
Increased serum creatine kinase (CPK) activity has been reported to be present during acute exacerbations of psychosis in the majority of patients with the major "functional" psychoses. It has also been demonstrated that mean serum CPK activity, ie, average daily serum CPK activity, is under genetic control. In this report, we present evidence for an association between the presence of a transient elevation of serum CPK activity beyond the upper limit of normal during psychotic episodes and relatively high mean serum CPK levels during the rest of hospitalization. The magnitude of the transient serum CPK elevation was correlated with mean serum CPK activity in psychotic patients. The mean serum CPK level was also correlated with the terminal innervation ratio, an indication of alpha motor neuron dysfunction. The incidence of serum CPK elevations in first-degree relatives of psychotic patients was significantly greater in patients with high mean serum CPK activity than in those with low mean serum CPK activity. High mean serum CPK activity may be an indication of an increase in permeability of the muscle cell membrane, which in turn may be due to some defect in the neurotrophic regulation of muscle physiology or an independent expression of muscle abnormalities.
据报道，大多数患有主要“功能性”精神病的患者在精神病急性发作期间血清肌酸激酶（CPK）活性会升高。也有研究表明，血清CPK平均活性，即每日血清CPK平均活性，受基因控制。在本报告中，我们提供证据表明，精神病发作期间血清CPK活性短暂升高超过正常上限与住院期间其余时间相对较高的血清CPK平均水平之间存在关联。精神病患者血清CPK短暂升高的幅度与血清CPK平均活性相关。血清CPK平均水平也与终末神经支配率相关，终末神经支配率是α运动神经元功能障碍的一个指标。精神病患者一级亲属中血清CPK升高的发生率，血清CPK平均活性高的患者显著高于血清CPK平均活性低的患者。血清CPK平均活性高可能表明肌肉细胞膜通透性增加，这反过来可能是由于肌肉生理的神经营养调节存在某些缺陷或肌肉异常的独立表现。
