Ikeda H
Folia Psychiatr Neurol Jpn. 1977;31(1):9-16. doi: 10.1111/j.1440-1819.1977.tb02678.x.
Serum CPK activity was measured for a total of 33 cases of chronic alcoholics who were admitted to the mental hospital from April, 1975 to January, 1976. The result was examined in relation to the manifestation of the psychotic symptoms in the patients: (1) Twenty six (78.8%) out of 33 cases showed increased serum CPK activity within 48 hours of admission. (2) In most cases that showed abnormal CPK activity, CPK value was the highest at the moment of admission, and then began to fall rapidly, and after one or two weeks settled to the normal CPK level. (3) There was a positive correlation between abnormal CPK activity and the manifestation of the psychotic symptoms in the month before and after entering hospital. In this cases of those having more than 101 IU in serum CPK value, the rate of presenting the psychotic symptoms in a month before or after admission was 90.5% and 71.4%, respectively. The author has given here a report on the above-mentioned results and made some considerations as to pathogenesis of abnormal CPK activity in chronic alcoholism.
对1975年4月至1976年1月期间入住精神病院的33例慢性酒精中毒患者进行了血清肌酸磷酸激酶（CPK）活性测定。研究结果与患者精神症状的表现相关：（1）33例患者中有26例（78.8%）在入院后48小时内血清CPK活性升高。（2）在大多数CPK活性异常的病例中，CPK值在入院时最高，随后迅速下降，一两周后降至正常CPK水平。（3）CPK活性异常与入院前后一个月内精神症状的表现呈正相关。血清CPK值超过101 IU的患者，入院前或入院后一个月出现精神症状的比例分别为90.5%和71.4%。作者在此报告上述结果，并对慢性酒精中毒中CPK活性异常的发病机制进行了一些思考。
