Pilz P, Wallnöfer H, Klein J
Arch Psychiatr Nervenkr (1970). 1980;228(1):31-43. doi: 10.1007/BF00365741.
A 28-year-old man suffered from recurrent facial exanthema, arthritis and stomatitis for ten years and died six months after a catatonic episode with terminal cerebral convulsions. Three years before his death high KBR-Antititers to Herpes simplex- and cytomegalic virus were observed, while Lupus-Erythematosus-Tests (LE-Tests) only became positive in the last months. At autopsy, changes compatible with Systemic Lupus Erythematosus (SLE) were found in the mitral valves, the spleen, and the kidneys. The brain displayed hemorrhagic infarction of the striate bodies and thrombophlebitis of the internal cerebral veins, the wall of which exhibited circumscribed infiltrations with numerous hematoxilin bodies and LE cells. This seems to be the first observation of LE-specific changes in the brain. The importance of cerebral vein affection in SLE involving the nervous system is stressed and a hypothesis submitted proposing the viral etiology of SLE.
一名28岁男性患复发性面部皮疹、关节炎和口腔炎10年，在一次紧张症发作伴末期脑惊厥6个月后死亡。死前三年观察到高滴度抗单纯疱疹病毒和巨细胞病毒的KBR抗体，而狼疮红斑试验（LE试验）仅在最后几个月呈阳性。尸检时，在二尖瓣、脾脏和肾脏发现了与系统性红斑狼疮（SLE）相符的病变。大脑显示纹状体出血性梗死和大脑内静脉血栓性静脉炎，其壁有局限性浸润，有大量苏木精小体和LE细胞。这似乎是首次观察到大脑中LE特异性变化。强调了SLE累及神经系统时脑静脉受累的重要性，并提出了SLE病毒病因的假说。
