短期无钙灌注后分离的大鼠肝脏的研究结果与分离的细胞相关吗？
Are findings with isolated rat livers after short calcium free perfusion relevant for isolated cells?
作者信息
Höke H, Krell H, Pfaff E
出版信息
Arch Toxicol. 1980 Mar;44(1-3):23-30. doi: 10.1007/BF00303180.
PMID:7387400
Abstract
In the isolated liver transient perfusion without calcium results in cholestasis which was characterized by an increased efflux rate across the sinusoidal membrane and inhibition of the concentrative transport of bromosulfophthalein to the canalicular side of the cell. Cholestasis could not be reversed within the usual duration of liver perfusion.
摘要
在离体肝脏的无钙短暂灌注中，会导致胆汁淤积，其特征是跨窦状隙膜的流出率增加以及溴磺酞向细胞胆小管侧的浓缩转运受到抑制。在肝脏灌注的通常持续时间内，胆汁淤积无法逆转。
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