Delwaide P J, Hurlet A
Arch Neurol. 1980 Jul;37(7):441-3. doi: 10.1001/archneur.1980.00500560071010.
Eight women with senile dementia and buccolinguofacial dyskinesias (BLFD) were given bromcriptine mesylate )from 2.5 to 20.0 mg daily). The frequency of their abnormal movements was quantiated by a method consisting of repeated counts (220 measurements per patient). In six patients, the mean frequency of BLFD was lower during bromocriptine mesylate therapy )even at daily doses of 10 mg or less) as compared with placebo; this result was statistically significant in four of the six. The second day after cessation of bromocriptine therapy, there seemed to be a rebound effect in six patients. These phenomena are discussed in light of the possible existence of presynaptic "autoreceptors" that would explain the paradoxical effects produced by a number of dopamine agonists.
八名患有老年痴呆症和颊舌面部运动障碍（BLFD）的女性接受了甲磺酸溴隐亭治疗（每日剂量为2.5至20.0毫克）。通过一种包括重复计数（每位患者进行220次测量）的方法对她们异常运动的频率进行了量化。在六名患者中，与安慰剂相比，甲磺酸溴隐亭治疗期间（即使每日剂量为10毫克或更低）BLFD的平均频率较低；这一结果在六名患者中的四名中具有统计学意义。溴隐亭治疗停止后的第二天，六名患者似乎出现了反跳效应。鉴于可能存在的突触前“自身受体”来解释多种多巴胺激动剂产生的矛盾效应，对这些现象进行了讨论。
