[Morphology of experimental acute pancreatitis during treatment with 5-fluorouracil].

Application of 5-fluorouracil exerts a noticeable therapeutic effect in experimental pancreatitis induced according to the modified technique. It prevents the development of acinus necrosis and suppurative lysis of the gland tissue. A suggestion is made that the therapeutic effect of 5-fluorouracil is related to its inhibitory action on RNA synthesis and to the blockade of secretion release from the exocrine part of the gland.