Drake S M, Evans B A, Gerken A
Br J Vener Dis. 1980 Apr;56(2):107-10. doi: 10.1136/sti.56.2.107.
The relationship between vaginal pH, microflora, and yeast infection was investigated in 93 women randomly treated with either nystatin or miconazole pessaries and cream for two weeks. The vaginal pH was measured in a control group of 48 women. In the study group, 37 patients defaulted, 39 were cured, and 17 required treatment during the six-month follow-up period. In both study and control groups before and after treatment the mean vaginal pH was in the range of 4.3-4.6. Lactobacilli were plentiful in 78 (91%) out of 86 patients and shows that lactobacilli and yeasts commonly coexist. The influence of other organisms appeared to be negligible. The trial showed that nystatin and micromazole were equallly effective in the treatment of vaginal yeast infection and that the broad-spectrum activity of micronazole offered no advantage in this condition.
对93名随机接受制霉菌素或咪康唑阴道栓剂及乳膏治疗两周的女性，研究了阴道pH值、微生物群与酵母菌感染之间的关系。对48名女性组成的对照组测量了阴道pH值。在研究组中，37名患者中途退出，39名治愈，17名在六个月的随访期内需要再次治疗。在治疗前后的研究组和对照组中，平均阴道pH值在4.3 - 4.6范围内。86名患者中有78名（91%）乳酸杆菌丰富，表明乳酸杆菌和酵母菌通常共存。其他微生物的影响似乎可以忽略不计。该试验表明，制霉菌素和咪康唑在治疗阴道酵母菌感染方面同样有效，且咪康唑的广谱活性在这种情况下并无优势。
