Juvancz P
Brain Res. 1980 Aug 4;194(2):371-6. doi: 10.1016/0006-8993(80)91218-4.
The midbrain raphe nuclei (nucleus raphe dorsalis and nucleus raphe medialis) were destroyed by electrocoaggulation in rats. On the first few days following the lesion, a marked hyperactivity was observed in lesioned animals as well as in shame-operated controls. Between the 5th and 36th days after the lesion, sleep patterns did not differ either qualitatively or quantitatively from the shame-operated and intact controls. The forebrain 5-HT level was reduced to 33.85%. It is concluded, that in rats restoration of the sleep system after the destruction of midbrain raphe nuclei is extremely rapid and effective. 5-HT seems to play an important role in this restored sleep system even though the forebrain 5-HT content was still markedly reduced.
通过电凝毁损大鼠的中脑缝核（背侧缝核和中缝核）。在损伤后的最初几天，损伤动物以及假手术对照组均出现明显的活动亢进。在损伤后第5天至36天之间，睡眠模式在质和量上与假手术组及未损伤对照组均无差异。前脑5-羟色胺（5-HT）水平降至33.85%。得出的结论是，大鼠中脑缝核破坏后睡眠系统的恢复极其迅速且有效。5-HT似乎在这个恢复的睡眠系统中发挥重要作用，尽管前脑5-HT含量仍显著降低。
