Ramot B, Modan M, Berkowicz M, Meytes D, Shochat J
Isr J Med Sci. 1978 Oct;14(10):1014-8.
The rate of occurrence of herpes zoster (HZ) was analyzed by the life table method in 108 Hodgkin's disease (HD) patients, diagnosed and treated during the years 1969 to 1976. Three groups, divided according to the degree of severity of the disease, were compared. The cumulative rate of occurrence of HZ at the end of the third year after diagnosis was higher in the group with intermediately extensive disease than in that with the most extensive disease (35 vs. 23%), but the difference was not significant. At the end of the fifth year, the rate was almost identical in both groups (35.3 and 35.6%, respectively). The group with the least severe form of HD had a very low HZ rate (2.2%), which was significantly different from the other two groups and close to the rate reported for normal populations. The five-year mortality rate was 0.0, 20.3 and 40.6%, respectively, in the three groups. These findings were interpreted to mean that in more advanced stages of HD, therapy and not the severity of the disease is the main factor determining the incidence of HZ. Extended field irradiation followed by a few courses of combined chemotherapy appear to have an effect similar to that of prolonged chemotherapy.
采用寿命表法分析了1969年至1976年间诊断和治疗的108例霍奇金病（HD）患者中带状疱疹（HZ）的发生率。根据疾病严重程度将患者分为三组并进行比较。诊断后第三年末，中度广泛病变组的HZ累积发生率高于最广泛病变组（35%对23%），但差异无统计学意义。第五年末，两组的发生率几乎相同（分别为35.3%和35.6%）。HD最轻型组的HZ发生率非常低（2.2%），与其他两组有显著差异，且接近正常人群报告的发生率。三组的五年死亡率分别为0.0%、20.3%和40.6%。这些发现被解释为意味着在HD的更晚期阶段，决定HZ发生率的主要因素是治疗而非疾病严重程度。扩大野照射后进行几个疗程的联合化疗似乎与长期化疗有相似的效果。
