促进肿瘤生长的特异性和非特异性免疫机制。

Specific and non-specific immunologic mechanisms of tumor growth facilitation.

作者信息

Yamagishi H, Pellis N R, Mokyr M B, Kahan B D

出版信息

Cancer. 1980 Jun 15;45(12):2929-33. doi: 10.1002/1097-0142(19800615)45:12<2929::aid-cncr2820451205>3.0.co;2-9.

DOI:10.1002/1097-0142(19800615)45:12<2929::aid-cncr2820451205>3.0.co;2-9

Abstract

Specific and non-specific mechanisms of tumor growth facilitation were studied using methylcholanthrene (MCA)-induced fibrosarcomas in C3H/HeJ mice. In early and late stages of tumor growth, mice possessed non-specific, tumor-facilitating cells detected by local adoptive transfer assay (LATA). These cells appeared to be macrophages; they were radioresistant (700 rads), phagocytic, and adherent to plastic. Specific tumor facilitation was induced by treatment either with crude 3M KCl extracts, or with an acidic pIEF fraction (pI 3.5). After treatment with this material, animals displayed facilitated outgrowth of only MCA-F, but not the antigenically distinct MCA-D or MCA-C tumors. Thus in addition to non-specific stimuli, which accelerate neoplastic growth, tumors bear tumor-specific transplantation antigens (TSTA), which induce specific facilitation.

摘要

利用甲基胆蒽（MCA）诱导C3H/HeJ小鼠产生纤维肉瘤，研究了促进肿瘤生长的特异性和非特异性机制。在肿瘤生长的早期和晚期，通过局部过继转移试验（LATA）检测到小鼠体内存在非特异性的肿瘤促进细胞。这些细胞似乎是巨噬细胞；它们具有放射抗性（700拉德），具有吞噬作用，并且能黏附于塑料制品上。用粗制的3M KCl提取物或酸性等电聚焦组分（pI 3.5）处理可诱导特异性肿瘤促进作用。用这种物质处理后，动物体内仅MCA-F肿瘤的生长得到促进，而抗原性不同的MCA-D或MCA-C肿瘤则没有。因此，除了加速肿瘤生长的非特异性刺激外，肿瘤还带有肿瘤特异性移植抗原（TSTA），可诱导特异性促进作用。