Kaplan H G, Doolittle C H
Cancer. 1980 Jun 15;45(12):3114-6. doi: 10.1002/1097-0142(19800615)45:12<3114::aid-cncr2820451239>3.0.co;2-x.
In the case reported here the patient presented with Stage IVB mixed cellularity Hodgkin's disease was complicated by massive splenomegaly, bone marrow infiltration with Hodgkin's disease, and severe pancytopenia. The pancytopenia was reversed by glucocorticosteroid therapy but recurred when steroids were tapered. Reinstitution of steroids resulted in recovery of peripheral blood counts, allowing administration of full-dose combination chemotherapy leading to a complete clinical remission and obviating the need for emergency splenectomy.
在本文报道的病例中，一名患有IVB期混合细胞型霍奇金病的患者出现了严重脾肿大、霍奇金病骨髓浸润及严重全血细胞减少等并发症。全血细胞减少通过糖皮质激素治疗得到缓解，但在激素减量时复发。重新使用激素导致外周血细胞计数恢复，从而能够给予全剂量联合化疗，实现了临床完全缓解，避免了急诊脾切除术。
