Pascale Florentina, Pelage Jean-Pierre, Wassef Michel, Ghegediban Saïda H, Saint-Maurice Jean-Pierre, De Baere Thierry, Denys Alban, Duran Rafael, Deschamps Frédéric, Pellerin Olivier, Maeda Noboru, Laurent Alexandre, Namur Julien
Research and Development Department, Archimmed Société à responsabilité limtée Limited liability Company (SARL), Jouy-en-Josas, France.
Université de Caen Normandie (UNICEAN), Centre d'Energie atomique (CEA), Centre National de la Recherche Scientifique, Imagerie et Stratégies Thérapeutiques pour les Cancers et Tissus Cérébraux CERVOxy (ISTCT-CERVOxy) Normandie University, Caen, France.
Front Oncol. 2022 May 10;12:871829. doi: 10.3389/fonc.2022.871829. eCollection 2022.
The rabbit VX2 is a large animal model of cancer used for decades by interventional radiologists to demonstrate the efficacy of various locoregional treatments against liver tumors. What do we know about this tumor in the new era of targeted therapy and immune-oncology? The present paper describes the current knowledge on the clinics, biology, histopathology, and tumor microenvironment of VX2 based on a literature review of 741 publications in the liver and in other organs. It reveals the resemblance with human cancer (anatomy, vascularity, angiogenic profile, drug sensitivity, immune microenvironment), the differences (etiology, growth rate, histology), and the questions still poorly explored (serum and tissue biomarkers, genomic alterations, immune checkpoint inhibitors efficacy).
兔VX2是一种癌症大动物模型，几十年来一直被介入放射科医生用于证明各种局部区域治疗对肝肿瘤的疗效。在靶向治疗和免疫肿瘤学的新时代，我们对这种肿瘤了解多少？本文基于对741篇关于肝脏和其他器官的出版物的文献综述，描述了目前关于VX2的临床、生物学、组织病理学和肿瘤微环境的知识。它揭示了与人类癌症的相似之处（解剖学、血管分布、血管生成特征、药物敏感性、免疫微环境）、差异（病因、生长速度、组织学）以及仍未充分探索的问题（血清和组织生物标志物、基因组改变、免疫检查点抑制剂疗效）。
