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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Wilcken D E, Gupta V J, Reddy S G

Clin Sci (Lond). 1980 May;58(5):427-30. doi: 10.1042/cs0580427.

Plasma sulphur-containing amino acids were measured in 19 patients with renal failure on chronic haemodialysis and in 22 normal subjects, to determine the rate of accumulation of these amino acids in chronic azotaemia. 2. Cysteine--homocysteine mixed disulphide was significantly increased in patients before dialysis and homocysteine was detected in low concentration in 10 patients. Cystine and taurine were also increased. Changes in other neutral and acidic amino acids were similar to those reported in chronic renal insufficiency. 3. In 3--4 h of dialysis serum creatinine was decreased by a mean of 55%, cysteine--homocysteine by 41% and cystine by 58.5% (P less than 0.001 for each). Methionine concentrations were normal throughout. 4. We conclude that sulphur-containing amino acids, except methionine, accumulate in chronic renal failure as rapidly as creatinine.

对19例慢性血液透析的肾衰竭患者及22名正常受试者测定血浆含硫氨基酸，以确定这些氨基酸在慢性氮质血症中的蓄积速率。2. 透析前患者的半胱氨酸 - 同型半胱氨酸混合二硫化物显著增加，10例患者检测到低浓度的同型半胱氨酸。胱氨酸和牛磺酸也增加。其他中性和酸性氨基酸的变化与慢性肾功能不全报道的相似。3. 在3 - 4小时的透析过程中，血清肌酐平均下降55%，半胱氨酸 - 同型半胱氨酸下降41%，胱氨酸下降58.5%（每项P均小于0.001）。甲硫氨酸浓度始终正常。4. 我们得出结论，除甲硫氨酸外，含硫氨基酸在慢性肾衰竭中的蓄积速度与肌酐一样快。

Wilcken D E, Gupta V J, Reddy S G

Clin Sci (Lond). 1980 May;58(5):427-30. doi: 10.1042/cs0580427.

Plasma sulphur-containing amino acids were measured in 19 patients with renal failure on chronic haemodialysis and in 22 normal subjects, to determine the rate of accumulation of these amino acids in chronic azotaemia. 2. Cysteine--homocysteine mixed disulphide was significantly increased in patients before dialysis and homocysteine was detected in low concentration in 10 patients. Cystine and taurine were also increased. Changes in other neutral and acidic amino acids were similar to those reported in chronic renal insufficiency. 3. In 3--4 h of dialysis serum creatinine was decreased by a mean of 55%, cysteine--homocysteine by 41% and cystine by 58.5% (P less than 0.001 for each). Methionine concentrations were normal throughout. 4. We conclude that sulphur-containing amino acids, except methionine, accumulate in chronic renal failure as rapidly as creatinine.

对19例慢性血液透析的肾衰竭患者及22名正常受试者测定血浆含硫氨基酸，以确定这些氨基酸在慢性氮质血症中的蓄积速率。2. 透析前患者的半胱氨酸 - 同型半胱氨酸混合二硫化物显著增加，10例患者检测到低浓度的同型半胱氨酸。胱氨酸和牛磺酸也增加。其他中性和酸性氨基酸的变化与慢性肾功能不全报道的相似。3. 在3 - 4小时的透析过程中，血清肌酐平均下降55%，半胱氨酸 - 同型半胱氨酸下降41%，胱氨酸下降58.5%（每项P均小于0.001）。甲硫氨酸浓度始终正常。4. 我们得出结论，除甲硫氨酸外，含硫氨基酸在慢性肾衰竭中的蓄积速度与肌酐一样快。