Thormann J, Wildenhoff K E
Contact Dermatitis. 1980 Apr;6(3):170-1. doi: 10.1111/j.1600-0536.1980.tb05591.x.
A total of 45 of 60 patients with herpes zoster previously treated with topical idoxuridine 5-40% in dimethylsulfoxide were patch tested 2 years later with idoxuridine 0.5% and 5% in petrolatum. Three (7%) showed positive reactions. Idoxuridine is considered a weak sensitizer, but in strong concentrations and in active solvents, which increases absorption, there seems to be a risk of sensitization.
60例曾用5%-40%碘苷二甲基亚砜溶液局部治疗的带状疱疹患者中,45例在2年后用0.5%和5%碘苷凡士林进行斑贴试验。3例(7%)出现阳性反应。碘苷被认为是一种弱致敏剂,但在高浓度及能增加吸收的活性溶剂中,似乎存在致敏风险。