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各种形式的心肌保护对心脏功能、代谢及血流的影响(作者译)

[Effects of various forms of myocardial protection on cardiac function, metabolism, and blood flow (author's transl)].

作者信息

Klooker P, Hilse B, Mittmann U, Saggau W, Tanzeem A, Weckler G J

出版信息

Chir Forum Exp Klin Forsch. 1980:285-90.

PMID:7389467
Abstract

The myocardial protective effect of two cardioplegic solutions was studied after an ischemic period of 2 h in eight dogs. Group I received a high potassium solution (St. Thomas Hospital) and group II a sodium withdrawal solution with high colloid osmotic pressure (Eppendorf solution). With the exception of a prolonged myocardial K+ washout (10 min) in group I, which was presumably responsible for fibrillation in the early reperfusion period, no major metabolic or perfusion differences between the two groups were observed. After 30 min of reperfusion, postischemic LV function (-43%) and O2 uptake (-43%) were equally reduced in both groups.

摘要

在八只狗经历2小时缺血期后,研究了两种心脏停搏液的心肌保护作用。第一组接受高钾溶液(圣托马斯医院溶液),第二组接受高胶体渗透压的钠洗脱溶液(埃彭多夫溶液)。除了第一组心肌钾离子洗脱时间延长(10分钟),这可能是早期再灌注期发生房颤的原因外,两组之间未观察到主要的代谢或灌注差异。再灌注30分钟后,两组缺血后左心室功能(-43%)和氧摄取量(-43%)均同等程度降低。

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