Ovcharova R, Iosifov T, Bantutova I
Eksp Med Morfol. 1980;19(1):30-6.
The authors carried out studies on 57 cats, made unmovable by curare and to whom under the conditions of acute experiment electrodes were introduced in the amygdala, hypothalamus, septum, mesencephalic reticular formation and cerebral cortex by means of a stereotaxic apparatus. Bioelectric activity from these structures was recorded by a polyphysiograph Hellige. The effect of alcohol, morphine, phenobarbital, diasepam, chlorpromasine, amphetamine and LSD was examined. All examined substances except chlropromasine induced excitation in amygdala, hypothalamus and septum. Morphine phenobarbital and diasepam inhibited mesencephalic reticular formation, but amphetamine and LSD-excitation. Chlorpromasine caused inhibition in all structures. On the basis of literary data that structures are included in the so called "rewarding system" the authors assume that drugs with narcotic effect induce excitation in this system in spite of their action on the cerebral cortex.
作者对57只猫进行了研究，这些猫用箭毒使其不能活动，并在急性实验条件下，通过立体定位仪将电极插入杏仁核、下丘脑、隔区、中脑网状结构和大脑皮层。用Hellige多生理记录仪记录这些结构的生物电活动。研究了酒精、吗啡、苯巴比妥、地西泮、氯丙嗪、苯丙胺和麦角酸二乙酰胺（LSD）的作用。除氯丙嗪外，所有受试物质均能引起杏仁核、下丘脑和隔区兴奋。吗啡、苯巴比妥和地西泮抑制中脑网状结构，但苯丙胺和LSD引起兴奋。氯丙嗪对所有结构均有抑制作用。根据文献资料，这些结构属于所谓的“奖赏系统”，作者认为，尽管具有麻醉作用的药物作用于大脑皮层，但它们仍能引起该系统兴奋。
