Kassem M A, Schulte K E
Eur J Drug Metab Pharmacokinet. 1980;5(1):25-8. doi: 10.1007/BF03189439.
The effect of benzyl nicotinate (15 mg) on the percutaneous absorption of dexamethasone 0,1 mg (62,5 uCi)/6 cm2, in an ethanol/octanol vehicle has been investigated in the rat. Both the urinary excretion and blood concentration data showed that benzyl nicotinate had a pronounced stimulating effect on the rate and extent of absorption. The relative bioavailability of dexamethasone was found to be 120% (urinary excretion data) or 146% (blood concentration data). Peak blood concentration increased greatly and was reached more quickly (1 1/2 hours instead of 2 1/2 hours).
在大鼠中研究了烟酸苄酯（15毫克）对乙醇/辛醇载体中0.1毫克（62.5微居里）地塞米松/6平方厘米经皮吸收的影响。尿液排泄和血药浓度数据均表明，烟酸苄酯对吸收速率和吸收程度有显著的促进作用。地塞米松的相对生物利用度分别为120%（尿液排泄数据）或146%（血药浓度数据）。血药浓度峰值大幅增加且达到更快（1.5小时而非2.5小时）。
