具有双重生化作用位点的喹唑啉抗叶酸剂。旨在克服甲氨蝶呤耐药性的生化与生物学研究。 - Suppr

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超能文献

Quinazoline antifolates with dual biochemical loci of action. Biochemical and biological studies directed towards overcoming methotrexate resistance.

作者信息

Calvert A H, Jones T R, Dady P J, Grzelakowska-Sztabert B, Paine R M, Taylor G A, Harrap K R

出版信息

Eur J Cancer (1965). 1980 May;16(5):713-22. doi: 10.1016/0014-2964(80)90214-5.

DOI:10.1016/0014-2964(80)90214-5

PMID:7389797

Abstract

摘要

相似文献

Quinazoline antifolates with dual biochemical loci of action. Biochemical and biological studies directed towards overcoming methotrexate resistance.具有双重生化作用位点的喹唑啉抗叶酸剂。旨在克服甲氨蝶呤耐药性的生化与生物学研究。

Eur J Cancer (1965). 1980 May;16(5):713-22. doi: 10.1016/0014-2964(80)90214-5.

Folate-pool interconversions and inhibition of biosynthetic processes after exposure of L1210 leukemia cells to antifolates. Experimental and network thermodynamic analyses of the role of dihydrofolate polyglutamylates in antifolate action in cells.L1210白血病细胞暴露于抗叶酸药物后叶酸池的相互转化及生物合成过程的抑制。二氢叶酸多聚谷氨酸盐在细胞抗叶酸作用中角色的实验及网络热力学分析。

J Biol Chem. 1989 Oct 15;264(29):17016-23.

Mechanisms of acquired resistance to the quinazoline thymidylate synthase inhibitor ZD1694 (Tomudex) in one mouse and three human cell lines.喹唑啉胸苷酸合成酶抑制剂ZD1694（拓扑替康）在一种小鼠细胞系和三种人类细胞系中获得性耐药的机制。

Br J Cancer. 1995 May;71(5):914-24. doi: 10.1038/bjc.1995.178.

Quinazoline antifolates inhibiting thymidylate synthase: synthesis of gamma-linked peptide and amide analogues of 2-desamino-2-methyl-N10-propargyl- 5,8-dideazafolic acid (ICI 198583).抑制胸苷酸合成酶的喹唑啉抗叶酸剂：2-脱氨基-2-甲基-N10-炔丙基-5,8-二去氮叶酸（ICI 198583）的γ-连接肽和酰胺类似物的合成

Adv Exp Med Biol. 1993;338:593-6. doi: 10.1007/978-1-4615-2960-6_121.

Inhibition of thymidylate synthetase by the new quinazoline antifolate, CB 3717; enzyme purification and kinetics.新型喹唑啉类抗叶酸剂CB 3717对胸苷酸合成酶的抑制作用；酶的纯化及动力学

Adv Exp Med Biol. 1984;165 Pt B:375-8. doi: 10.1007/978-1-4757-0390-0_71.

The duration of the inhibition of thymidylate synthase in intact L1210 cells exposed to two different classes of quinazoline analogues.暴露于两类不同喹唑啉类似物的完整L1210细胞中胸苷酸合成酶的抑制持续时间。

Adv Exp Med Biol. 1993;338:597-600. doi: 10.1007/978-1-4615-2960-6_122.

Estimation of the in vitro and in vivo inhibitory effects of antifolates upon thymidylate synthase (TS) in whole cells.

Adv Exp Med Biol. 1989;253B:383-8. doi: 10.1007/978-1-4684-5676-9_56.

Quinazoline antifolates: biologic activities.

Cancer Chemother Rep. 1968 Dec;52(7):697-705.

A potent antitumour quinazoline inhibitor of thymidylate synthetase: synthesis, biological properties and therapeutic results in mice.一种强效的胸苷酸合成酶喹唑啉类抗肿瘤抑制剂：合成、生物学特性及对小鼠的治疗效果

Eur J Cancer (1965). 1981 Jan;17(1):11-9. doi: 10.1016/0014-2964(81)90206-1.

Design and synthesis of Cyclopenta[g]quinazoline-based antifolates as inhibitors of thymidylate synthase and potential antitumor agents(,).

J Med Chem. 2000 May 18;43(10):1910-26. doi: 10.1021/jm991119p.

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Deoxyuridine triphosphatase (dUTPase) expression and sensitivity to the thymidylate synthase (TS) inhibitor ZD9331.脱氧尿苷三磷酸酶（dUTPase）的表达及对胸苷酸合成酶（TS）抑制剂ZD9331的敏感性

Br J Cancer. 2000 Sep;83(6):792-9. doi: 10.1054/bjoc.2000.1358.

Clinical studies with MTA.使用MTA的临床研究。

Br J Cancer. 1998;78 Suppl 3(Suppl 3):35-40. doi: 10.1038/bjc.1998.752.

The relationship between intrinsic thymidylate synthase expression and sensitivity to THYMITAQ in human leukaemia and colorectal carcinoma cell lines.人白血病和结肠癌细胞系中内源性胸苷酸合成酶表达与对THYMITAQ敏感性之间的关系。

Br J Cancer. 1997;76(12):1579-85. doi: 10.1038/bjc.1997.600.

Biological activity and intracellular metabolism of ZD1694 in human leukemia cell lines with different resistance mechanisms to antifolate drugs.ZD1694在对抗叶酸药物具有不同耐药机制的人白血病细胞系中的生物活性和细胞内代谢

Jpn J Cancer Res. 1996 Jul;87(7):773-80. doi: 10.1111/j.1349-7006.1996.tb00291.x.

Cellular pharmacokinetics of ZD1694 in cultured human leukaemia cells sensitive, or made resistant, to this drug.ZD1694在对该药物敏感或已产生耐药性的培养人白血病细胞中的细胞药代动力学。

J Cancer Res Clin Oncol. 1996;122(2):109-17. doi: 10.1007/BF01226268.

Differential alterations of dihydrofolate reductase gene in human leukemia cell lines made resistant to various folate analogues.对多种叶酸类似物产生抗性的人白血病细胞系中二氢叶酸还原酶基因的差异改变。

Jpn J Cancer Res. 1993 Jan;84(1):9-12. doi: 10.1111/j.1349-7006.1993.tb02776.x.

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