Quinazoline antifolates: biologic activities. - Suppr | 超能文献

Quinazoline antifolates: biologic activities.

作者信息

Hutchison D J

出版信息

Cancer Chemother Rep. 1968 Dec;52(7):697-705.

Abstract

摘要

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Quinazoline antifolates: biologic activities.

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Quinazoline antifolates as inhibitors of dihydrofolate reductase from human leukemia cells.喹唑啉抗叶酸剂作为人白血病细胞二氢叶酸还原酶的抑制剂

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Quinazoline antifolates with dual biochemical loci of action. Biochemical and biological studies directed towards overcoming methotrexate resistance.具有双重生化作用位点的喹唑啉抗叶酸剂。旨在克服甲氨蝶呤耐药性的生化与生物学研究。

Eur J Cancer (1965). 1980 May;16(5):713-22. doi: 10.1016/0014-2964(80)90214-5.

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Uptake and efficacy of trimetrexate (TMQ, 2,4-diamino-5-methyl-6-[(3,4,5-trimethoxyanilino)methyl] quinazoline), a non-classical antifolate in methotrexate-resistant leukemia cells in vitro.三甲曲沙（TMQ，2,4-二氨基-5-甲基-6-[(3,4,5-三甲氧基苯胺基)甲基]喹唑啉）在耐甲氨蝶呤白血病细胞中的体外摄取及疗效，一种非经典抗叶酸剂

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Quinazolines as inhibitors of dihydrofolate reductase. 4. Classical analogues of folic and isofolic acids.

J Med Chem. 1977 Apr;20(4):588-91. doi: 10.1021/jm00214a030.

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Studies with a 2,4-diamino-5-chloro-quinazoline antifolate: in vitro and invivo correlates in normal and lymphosarcoma dogs.一项关于2,4-二氨基-5-氯喹唑啉抗叶酸剂的研究：正常犬和淋巴肉瘤犬的体内外相关性

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Inhibition of thymidylate synthetase by the new quinazoline antifolate, CB 3717; enzyme purification and kinetics.新型喹唑啉类抗叶酸剂CB 3717对胸苷酸合成酶的抑制作用；酶的纯化及动力学

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Selection and characterization of mutant strains of Streptococcus faecium var. durans resistant to methasquin and amethopterin.粪肠球菌耐久亚种对甲喹酮和氨甲蝶呤耐药突变株的筛选与鉴定

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Quinazoline antifolates: dosage schedules and toxicity.

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Synthesis and evaluation of 2,4-diaminoquinazoline antifolates with activity against methotrexate-resistant human tumor cells.对甲氨蝶呤耐药的人肿瘤细胞具有活性的2,4-二氨基喹唑啉抗叶酸剂的合成与评价

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引用本文的文献

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Dihydrofolate reductase activity in strains of Streptococcus faecium var. durans resistant to methasquin and amethopterin.粪肠球菌耐久亚种对甲喹酮和氨甲蝶呤耐药菌株中的二氢叶酸还原酶活性

J Bacteriol. 1972 Apr;110(1):139-45. doi: 10.1128/jb.110.1.139-145.1972.

2

Carboxypeptidase displaying differential velocity in hydrolysis of methotrexate, 5-methyltetrahydrofolic acid, and leucovorin.羧肽酶在甲氨蝶呤、5-甲基四氢叶酸和亚叶酸水解中表现出不同的速度。

J Bacteriol. 1978 May;134(2):506-13. doi: 10.1128/jb.134.2.506-513.1978.