Manukhin B N, Mukhammedov A, Berdysheva L V, Putintseva T G, Volina E V
Fiziol Zh SSSR Im I M Sechenova. 1980 Mar;66(3):344-9.
The rats desympathised with guanetidine developed a 58% decrease of the noradrenaline content in the myocardium, 37% - in the deferent duct, and 82% - in the small intestine. No significant changes of the catecholamines content occurred either in adrenal glands or in the hypothalamus. Sensitivity of the deferent duct's adrenoreceptors increased by 9 times. Sensitivity of the small intestine to noradrenaline increased by 3.4 times whereas the sensitivity to the antagonistic transmitter acetylcholine decreased by 2.4 times. Local adaptation mechanisms maintaining functioning of the organism in chronic desympathisation, are regarded.
用胍乙啶去交感神经的大鼠，心肌中去甲肾上腺素含量降低了58%，输精管中降低了37%，小肠中降低了82%。肾上腺或下丘脑的儿茶酚胺含量未发生显著变化。输精管肾上腺素能受体的敏感性增加了9倍。小肠对去甲肾上腺素的敏感性增加了3.4倍，而对拮抗递质乙酰胆碱的敏感性降低了2.4倍。文中探讨了在慢性去交感神经状态下维持机体功能的局部适应机制。
