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[去甲肾上腺素含量改变后离体大鼠器官的肾上腺敏感性]

[Adrenosensitivity of isolated rat organs after a change in their noradrenaline content].

作者信息

Berdysheva L V, Manukhin B N, Putintseva T G, Melent'eva A A

出版信息

Fiziol Zh SSSR Im I M Sechenova. 1978 Jun;64(6):758-65.

PMID:680262
Abstract

The 30-day dynamics of noradrenaline contents after a single administration of guanitidine (50 mg/kg) was similar in the heart and small intestine but different in the vas deferens. The decrease of the noradrenaline content in the small intestine and vas deferens duct was followed by an increase of their adrenosensitivity, and the restoration of noradrenaline level--by a decrease of the adrenosensitivity, which reveals an invert relationship between these parameters (the correlation coefficient for small intestine being 0.78 and for vas deferens duct--0.61). The role of the catecholamine level near the adrenoreceptors in regulation of the adrenosensitivity of effectors is discussed.

摘要

单次给予胍乙啶(50毫克/千克)后,心脏和小肠中去甲肾上腺素含量的30天动态变化相似,但在输精管中有所不同。小肠和输精管中去甲肾上腺素含量降低后,其肾上腺敏感性增加;去甲肾上腺素水平恢复后,肾上腺敏感性降低,这揭示了这些参数之间的反向关系(小肠的相关系数为0.78,输精管的相关系数为0.61)。文中讨论了肾上腺素能受体附近儿茶酚胺水平在调节效应器肾上腺敏感性中的作用。

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