[Study of the possible metabolic action of vasopressin under physiological conditions].

Blood free fatty acids (FFA) concentration was studied during 3 hrs after administration of I ml sunflower oil in consious normal and Brattleboro rats. Fasting FFA levels were similar in both groups of animals. In normal rats FFA concentration did not change significantly during the first 2 hrs after fat ingestion, the increase being observed to the end of the 3d hr. In DI-rats there was an increase in the concentration already to the end of the 1st hr which persisted till the end of experiment. The difference in FFA dynamics was observed just at the period when an antidiuretic reaction to fat ingestion was developed in normal animal. To establish whether the difference in FFA dynamics is actually due to the antilipolytic effect of vasopressin released after fat ingestion it is necessary to exclude the action of the hormone on fat absorption.