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[生理条件下血管加压素可能的代谢作用研究]

[Study of the possible metabolic action of vasopressin under physiological conditions].

作者信息

Abel'son Iu O

出版信息

Fiziol Zh SSSR Im I M Sechenova. 1980 Mar;66(3):404-8.

PMID:7389928
Abstract

Blood free fatty acids (FFA) concentration was studied during 3 hrs after administration of I ml sunflower oil in consious normal and Brattleboro rats. Fasting FFA levels were similar in both groups of animals. In normal rats FFA concentration did not change significantly during the first 2 hrs after fat ingestion, the increase being observed to the end of the 3d hr. In DI-rats there was an increase in the concentration already to the end of the 1st hr which persisted till the end of experiment. The difference in FFA dynamics was observed just at the period when an antidiuretic reaction to fat ingestion was developed in normal animal. To establish whether the difference in FFA dynamics is actually due to the antilipolytic effect of vasopressin released after fat ingestion it is necessary to exclude the action of the hormone on fat absorption.

摘要

在清醒的正常大鼠和布氏大鼠中,在给予1毫升葵花籽油后的3小时内研究了血液游离脂肪酸(FFA)浓度。两组动物的空腹FFA水平相似。在正常大鼠中,脂肪摄入后的前2小时内FFA浓度没有显著变化,在第3小时末观察到升高。在尿崩症大鼠中,到第1小时末浓度就已经升高,并持续到实验结束。FFA动态的差异恰好在正常动物对脂肪摄入产生抗利尿反应的时期被观察到。为了确定FFA动态的差异是否实际上是由于脂肪摄入后释放的血管加压素的抗脂解作用,有必要排除该激素对脂肪吸收的作用。

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