Abel'son Iu O
Fiziol Zh SSSR Im I M Sechenova. 1976 Dec;62(12):1863-9.
The fat antidiuretic effect was studied in rats with inhereted diabetes insipidus (DI rats). In these animals the decrease of urine flow after fat ingestion was less stable and less profound as compared with non--DI: sunflower oil produced no effect in 12 DI rats out of 19, the per cent of inhibition in the other 7 being not more than 50%. No changes in urine osmalality were observed during the period of fat inhibition, while a significant decrease in creatinine excretion was revealed. Fat antidiuresis in DI rats was not affected by ethanol administration. These findings corroborate the assumption that fat ingestion in healthy animals is accompanied by the ADH release. It seems that changes in glomerular filtration rate are involved in the mechanism of this kind of antidiuretic response, at least in rats with impaired ADH secretion
在遗传性尿崩症大鼠（DI大鼠）中研究了脂肪的抗利尿作用。与非DI大鼠相比，这些动物摄入脂肪后尿流量的减少不太稳定且不太显著：19只DI大鼠中有12只对葵花籽油无反应，另外7只的抑制百分比不超过50%。在脂肪抑制期间未观察到尿渗透压的变化，而肌酐排泄量显著降低。给DI大鼠注射乙醇不影响脂肪的抗利尿作用。这些发现证实了健康动物摄入脂肪会伴随抗利尿激素释放的假设。似乎肾小球滤过率的变化参与了这种抗利尿反应的机制，至少在抗利尿激素分泌受损的大鼠中是这样。
