Stokholm K H, Brøchner-Mortensen J, Hoilund-Carlsen P F
Int J Obes. 1980;4(1):57-63.
Glomerular filtration rate (GFR) was measured in 16 obese women aged 28-48 years (overweight 65-110 per cent) and compared to GFR in 16 non-obese women of the same age and height. None of the women had signs of nephrourological disorders. GFR was determined from the total 51 Cr-EDTA plasma clearance measured by a simplified single-injection technique. In the obese women GFR (median value 129.0 ml/min) was significantly (P less than 0.002) increased by 24.6 per cent. The urinary excretion rate of 17-ketogenic steroids was increased in nine out of 14 obese women, but no correlation with GFR could be demonstrated. GFR in the obese women showed a significant positive correlation with the plasma cortisol concentration (rs = 0.77; P less than 0.01) and with the urinary excretion rate of free cortisol (rs = 0.78; P less than 0.01). Whether the correlation between the plasma cortisol concentration and the increased GFR in obese women is causal needs further investigation.
对16名年龄在28 - 48岁的肥胖女性（超重65% - 110%）测量了肾小球滤过率（GFR），并将其与16名年龄和身高相同的非肥胖女性的GFR进行比较。这些女性均无肾泌尿系统疾病迹象。GFR通过简化单次注射技术测量的总51 Cr - EDTA血浆清除率来确定。肥胖女性的GFR（中位数为129.0毫升/分钟）显著升高（P < 0.002），升高了24.6%。14名肥胖女性中有9名的17 - 生酮类固醇尿排泄率升高，但未发现其与GFR有相关性。肥胖女性的GFR与血浆皮质醇浓度呈显著正相关（rs = 0.77；P < 0.01），与游离皮质醇尿排泄率也呈显著正相关（rs = 0.78；P < 0.01）。肥胖女性血浆皮质醇浓度与升高的GFR之间的相关性是否具有因果关系尚需进一步研究。
