Stokholm K H, Høilund-Carlsen P F, Brøchner-Mortensen J
Int J Obes. 1981;5(1):77-80.
Glomerular filtration rate (GFR), concentration of total cortisol in plasma, and urinary excretion rate of free cortisol were determined in five females 1-5 years after jejunoileal bypass operation for obesity. The overweight of the patients had decreased from 97 per cent (range 82-147 per cent) to 25 per cent (range 0-39 per cent). The measured values were compared to previously published results in 16 female obese patients (median overweight 86 per cent) and in 16 female controls with normal body weight, all comparable with respect to age and height. Median GFR in the jejunoileal bypass patients (100 ml/min) was significantly (P less than 0.006) decreased compared to median GFR in the obese patients (129 ml/min), but did not differ significantly from that in the controls with normal body weight (104 ml/min). The median values of plasma cortisol and urinary excretion rate of free cortisol in the bypass patients were lower than those in the obese females, but the differences were not significant. The present results suggest that the increased GFR in obese subjects is related to the state of obesity.
对5名女性进行空肠回肠分流术治疗肥胖症，术后1至5年测定其肾小球滤过率（GFR）、血浆总皮质醇浓度和游离皮质醇尿排泄率。患者的超重比例从97%（范围82 - 147%）降至25%（范围0 - 39%）。将测量值与先前发表的16名女性肥胖患者（超重中位数86%）和16名体重正常的女性对照者的结果进行比较，所有这些对照者在年龄和身高方面均具有可比性。空肠回肠分流术患者的GFR中位数（100 ml/分钟）与肥胖患者的GFR中位数（129 ml/分钟）相比显著降低（P小于0.006），但与体重正常的对照者（104 ml/分钟）相比无显著差异。分流术患者血浆皮质醇和游离皮质醇尿排泄率的中位数低于肥胖女性，但差异不显著。目前的结果表明，肥胖受试者GFR升高与肥胖状态有关。
