Schutten W H, Van Horn D L
Invest Ophthalmol Vis Sci. 1980 Jul;19(7):829-32.
The effect of increased hydrostatic pressure upon the ability of normal and regenerated endothelium to deturgesce preswollen, de-epithelialized rabbit corneas was studied. Stromal deturgescence occurred as a biphasic response when hydrostatic pressure at the endothelial surface was increased above baseline values. Initially there was a rapid phase of stromal thinning which was dependent upon hydrostatic pressure nad endothelial function. This was followed by a slower phase of corneal thinning which was independent of hydrostatic pressure at the endothelial surface for pressures between 15 and 50 mm Hg. The slow phase of thinning represents the steady-state ability of the endothelium to deturgesce the stroma. Regenerated rabbit endothelium functioned similarly to normal endothelium in deturgescing the stroma. In addition, short-term increases in hydrostatic pressure at the endothelial surface did not produce ultrastructural changes in normal or regenerated corneal endothelial cells.
研究了增加静水压力对正常内皮和再生内皮使预先肿胀、去上皮化的兔角膜消肿能力的影响。当内皮表面的静水压力增加到基线值以上时，基质消肿表现为双相反应。最初有一个基质变薄的快速阶段，这取决于静水压力和内皮功能。随后是角膜变薄的较慢阶段，对于15至50毫米汞柱之间的压力，该阶段与内皮表面的静水压力无关。变薄的缓慢阶段代表内皮使基质消肿的稳态能力。再生的兔内皮在使基质消肿方面的功能与正常内皮相似。此外，内皮表面静水压力的短期增加在正常或再生的角膜内皮细胞中未产生超微结构变化。
