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儿童期洋地黄中毒

Massive digoxin intoxication in childhood.

作者信息

Stopfkuchen H, Gilfrich H J, Jüngst B K, Gempp W

出版信息

Intensive Care Med. 1978 Nov;4(4):199-201. doi: 10.1007/BF01902547.

DOI:10.1007/BF01902547
PMID:739078
Abstract

In a 10 year old boy 8 hours after taking about 16 mg beta-acetyl-digoxin a maximum serum digoxin level of 31.8 ng/ml was measured radioimmunologically. This is the highest digitalis level in childhood described to date. The serum potassium level rose to 7.4 mmol/l. Complete atrio-ventricular block, and salves of ventricular premature beats were the most serious rhythm disturbances. The absence of life threatening rhythm disturbances is attributed to the early use of diphenylhydantoin in small frequent doses.

摘要

一名10岁男孩服用约16毫克β-乙酰地高辛8小时后,通过放射免疫法测得血清地高辛最高水平为31.8纳克/毫升。这是迄今为止所描述的儿童期最高的洋地黄水平。血清钾水平升至7.4毫摩尔/升。完全性房室传导阻滞和室性早搏的发作是最严重的节律紊乱。未出现危及生命的节律紊乱归因于早期小剂量频繁使用苯妥英。

相似文献

1
Massive digoxin intoxication in childhood.儿童期洋地黄中毒
Intensive Care Med. 1978 Nov;4(4):199-201. doi: 10.1007/BF01902547.
2
Phenytoin (diphenylhydantoin) treatment of massive digoxin overdose.苯妥英钠(二苯乙内酰脲)治疗大量地高辛过量
Br Heart J. 1974 Apr;36(4):405-8. doi: 10.1136/hrt.36.4.405.
3
The use of digoxin-specific Fab fragments for severe digitalis intoxication in children.地高辛特异性Fab片段在儿童严重洋地黄中毒中的应用。
N Engl J Med. 1992 Jun 25;326(26):1739-44. doi: 10.1056/NEJM199206253262604.
4
[Digitalis intoxication: specifity and significance of cardiac and extracardiac symptoms. part I: Patients with digitalis-induced arrhythmias (author's transl)].洋地黄中毒:心脏及心脏外症状的特异性和意义。第一部分:洋地黄所致心律失常患者(作者译)
Z Kardiol. 1977 Mar;66(3):121-8.
5
Extreme digitalis intoxication.极度洋地黄中毒
Acta Med Scand. 1976;200(5):423-5. doi: 10.1111/j.0954-6820.1976.tb08256.x.
6
[Can peak serum digoxin concentration be a sign of acute poisoning severity? Analysis of two cases of digoxin poisoning].[血清地高辛峰值浓度能否作为急性中毒严重程度的指标?两例地高辛中毒病例分析]
Pol Arch Med Wewn. 1998 Oct;100(4):344-9.
7
A case of self-induced digoxin poisoning: with His bundle studies of the site of heart block.一例洋地黄自服中毒病例:伴希氏束心脏传导阻滞部位研究
N Z Med J. 1976 Dec 8;84(577):443-6.
8
Acute massive digoxin overdose: survival without use of digitalis-specific antibodies.急性大剂量地高辛过量:未使用洋地黄特异性抗体而存活。
Am J Emerg Med. 1986 Jul;4(4):364-8. doi: 10.1016/0735-6757(86)90311-6.
9
[Severe digoxin intoxication in a 15-year-old girl treated with Fab antidigoxin].[15岁女孩因地高辛中毒接受抗地高辛Fab片段治疗]
Rev Esp Cardiol. 1996 Apr;49(4):311-3.
10
Massive digoxin intoxication. Report of a case with serum digoxin level correlation.大量地高辛中毒。1例血清地高辛水平相关性病例报告。
Acta Cardiol. 1975;30(5):375-82.

引用本文的文献

1
Digitalis toxicity in infants and children.婴幼儿洋地黄中毒
Pediatr Cardiol. 1984 Apr-Jun;5(2):131-48. doi: 10.1007/BF02424966.

本文引用的文献

1
Determination of therapeutic and toxic serum digoxin concentrations by radioimmunoassay.采用放射免疫分析法测定治疗性和中毒性血清地高辛浓度。
N Engl J Med. 1969 Nov 27;281(22):1212-6. doi: 10.1056/NEJM196911272812203.
2
Phenytoin (diphenylhydantoin) treatment of massive digoxin overdose.苯妥英钠(二苯乙内酰脲)治疗大量地高辛过量
Br Heart J. 1974 Apr;36(4):405-8. doi: 10.1136/hrt.36.4.405.
3
[Suicidal digoxin intoxication with hyperkalaemia: report of a case (author's transl)].自杀性地高辛中毒伴高钾血症:一例报告(作者译)
Dtsch Med Wochenschr. 1974 Apr 12;99(15):756-64. doi: 10.1055/s-0028-1107839.
4
Massive intravenous digoxin overdosage.大量静脉注射地高辛过量。
N Engl J Med. 1974 Oct 10;291(15):777-8. doi: 10.1056/NEJM197410102911508.
5
Suicidal and accidental digoxin ingestion. Report of five cases with serum digoxin level correlations.自杀性和意外性地高辛摄入。5例血清地高辛水平相关性报告。
Circulation. 1971 Jul;44(1):29-36. doi: 10.1161/01.cir.44.1.29.
6
[Hemodialysis in a child with accidental digitalis poisoning (author's transl)].一名意外洋地黄中毒儿童的血液透析(作者译)
Monatsschr Kinderheilkd (1902). 1976 Feb;124(2):82-4.
7
[Treatment of severe digitalis-intoxication in suicidal attempt (author's transl)].自杀未遂中严重洋地黄中毒的治疗(作者译)
Med Klin. 1975 May 2;70(18):812-6.