Jao W, Vazquez L T, Keh P C, Gould V E
J Pathol. 1978 Oct;126(2):107-12. doi: 10.1002/path.1711260209.
Sixteen cases of breast fibroadenomas and 11 of adenosis were studied ultrastructurally; emphasis was placed on the patterns of myoepithelial differentiation and the number and appearance of the basal laminae. Ducts of both fibroadenomas and adenosis showed well differentiated, peripherally arranged myoepithelial elements with conspicuous cytoplasmic filaments and numerous hemidesmosomes; focal myoepithelial multilayering occurred. Myoepithelial cells exhibited complex, convoluted cytoplasmic processes extending into the stroma and resulting in the formation of pseudocysts containing stromal material. Basal lamina deposition was invariably found; basal lamina reduplication was extremely frequent. Basal lamina discontinuities with cytoplasmic processes extending directly into the stroma were seen in adenosis. Myoepithelial features and conspicuous basal lamina deposition indicate advanced differentiation and correlate well with the benign prognosis of these lesions. The focal basal lamina gaps in adenosis may be significant in the long-term evolution of this and similar dysplastic processes.
对16例乳腺纤维腺瘤和11例腺病进行了超微结构研究；重点关注肌上皮分化模式以及基底膜的数量和外观。纤维腺瘤和腺病的导管均显示出分化良好、周边排列的肌上皮成分，具有明显的细胞质细丝和大量半桥粒；出现局灶性肌上皮多层化。肌上皮细胞表现出复杂的、卷曲的细胞质突起延伸至间质，导致形成含有间质物质的假囊肿。总是能发现基底膜沉积；基底膜重复极为常见。在腺病中可见基底膜连续性中断，细胞质突起直接延伸至间质。肌上皮特征和明显的基底膜沉积表明分化程度高，与这些病变的良性预后密切相关。腺病中的局灶性基底膜间隙可能在这种及类似发育异常过程的长期演变中具有重要意义。
