Pearson D E, Teicher M H, Shaywitz B A, Cohen D J, Young J G, Anderson G M
Science. 1980 Aug 8;209(4457):715-7. doi: 10.1126/science.7394533.
There is less hyperactive motor activity and better avoidance performance in rat pups treated with 6-hydroxydopamine as neonates and reared with vehicle-treated littermates than in pups reared in litters composed solely of other 6-hydroxydopamine-treated animals. Thus, in this experimental model of hyperactivity, an environmental manipulation provides an alternative to pharmacologic agents in reducing activity and improving learning performance.
与仅由其他经6-羟基多巴胺处理的动物组成的窝中饲养的幼崽相比，新生时用6-羟基多巴胺处理并与用赋形剂处理的同窝幼崽一起饲养的大鼠幼崽的多动活动较少，回避性能更好。因此，在这个多动实验模型中，环境操纵在降低活动水平和改善学习性能方面提供了一种替代药物的方法。
