McLean J H, Kostrzewa R M, May J G
Pharmacol Biochem Behav. 1976 May;4(5):601-7. doi: 10.1016/0091-3057(76)90203-3.
Rats receiving injection of either 6-hydroxydopa (60 mug/g) or saline on Days 1, 3, and 5 of life were studied in adulthood on a number of behavioral tasks before being sacrificed at 8 or 12 months for NE assay. The treated rats exhibited impaired passive avoidance, less shock-induced aggression, and more locomotor open-field activity than the control rats. There were no differences between the groups in male copulatory behavior, food and water intake, or thermoregulation. In comparison to the saline rats, 6-hydroxydopa rats showed elevated levels of endogenous NE in lower brainstem regions, e.g., midbrain and pons-medulla, as well as cerebellum. Hypothalamic NE level was not affected. Significant depletions of NE were obtained in the hippocampus and neocortex.
在出生后的第1、3和5天接受6-羟基多巴胺（60微克/克）或生理盐水注射的大鼠，在成年后接受了多项行为任务测试，然后在8或12个月时被处死以进行去甲肾上腺素（NE）测定。与对照大鼠相比，接受治疗的大鼠表现出被动回避受损、电击诱导的攻击性降低以及在旷场中的运动活动增加。两组在雄性交配行为、食物和水摄入量或体温调节方面没有差异。与生理盐水处理的大鼠相比，6-羟基多巴胺处理的大鼠在下脑干区域，如中脑、脑桥-延髓以及小脑中，内源性NE水平升高。下丘脑NE水平未受影响。海马体和新皮层中的NE显著减少。
