Buehler B A
Ann Clin Lab Sci. 1980 May-Jun;10(3):195-7.
Polyamines, polycationic compounds found in urine and sera of mammals, are elevated in patients with malignancies. Like carcinoembryonic antigen, these organic structures have been investigated as potential diagnostic tools in screening at-risk individuals for cancer and for predicting prognosis. In many instances, the ubiquity of these compounds and the lack of specificity for each malignancy have negated their usefulness. Recently, investigations have included some of the endocrine carcinomas and the relationships of urine or serum polyamine measurements. This article indicates the preliminary work that has been done and future directions for the significance of polyamine measurements in urine in carcinogenesis of the endocrine glands.
多胺是在哺乳动物尿液和血清中发现的聚阳离子化合物，在恶性肿瘤患者中含量升高。与癌胚抗原一样，这些有机结构已被作为潜在的诊断工具进行研究，用于筛查癌症高危个体和预测预后。在许多情况下，这些化合物的普遍存在以及对每种恶性肿瘤缺乏特异性，使其失去了实用性。最近的研究包括一些内分泌癌以及尿液或血清多胺测量之间的关系。本文指出了已开展的初步工作以及尿液中多胺测量在内分泌腺致癌作用中的意义的未来研究方向。
