Tsai L Y, Lian S L, Lee S C
Department of Clinical Laboratory, Kaohsiung Medical College, Taiwan, Republic of China.
Gaoxiong Yi Xue Ke Xue Za Zhi. 1991 Aug;7(8):413-8.
A new and simple enzymatic assay utilizing an acylpolyamine amidohydrolase and putrescine oxidase was adopted for measuring urinary polyamines (U-Pa). Serum carcinoembryonic antigen (S-CEA) was determined for comparison. The study population consisted of patients with pathologically proven nasopharyngeal carcinoma (NPC) who were referred to Kaohsiung Medical College Hospital. We found that polyamine levels were markedly elevated during radiotherapy but declined when the treatment was completed. Thus mean polyamines and the positive rate of polyamine elevation was higher in patients suffering from an active stage of the disease than in patients whose cancer had stabilized. However, the level of carcinoembryonic antigen was not elevated whilst undergoing radiotherapy. Therefore, routine measurement of polyamine levels may have a clinical utility in monitoring the disease state of the tumor. However, the low sensitivity of U-Pa test (22%) precludes its use as an effective screening method for this condition. Nevertheless, because of its simplicity, convenience and rapidity for monitoring NPC, U-Pa test should be considered a valuable tool in the clinical investigation of NPC patients.
采用一种利用酰基多胺酰胺水解酶和腐胺氧化酶的新型简单酶法来测定尿多胺（U-Pa）。测定血清癌胚抗原（S-CEA）以作比较。研究对象为转诊至高雄医学院医院且经病理证实患有鼻咽癌（NPC）的患者。我们发现，放疗期间多胺水平显著升高，但治疗结束后下降。因此，处于疾病活动期的患者的平均多胺水平及多胺升高的阳性率高于癌症已稳定的患者。然而，放疗期间癌胚抗原水平并未升高。因此，常规检测多胺水平可能在监测肿瘤疾病状态方面具有临床应用价值。然而，U-Pa检测的低灵敏度（22%）使其无法用作该病的有效筛查方法。尽管如此，由于U-Pa检测在监测鼻咽癌方面具有简便、便捷和快速的特点，应将其视为鼻咽癌患者临床研究中的一种有价值的工具。
