麦角新碱和溴隐亭对高催乳素血症患者催乳素释放的抑制作用：比较动态研究（作者译）

[Inhibition of prolactin release by methysergide and bromocriptine in hyperprolactinemic subjects: comparative dynamic studies (author's transl)].

作者信息

Fossati P, Dewailly D, Lemaire A, Cappoen J P, Wemeau J L, Fourlinnie J C, Linquette M

出版信息

Ann Endocrinol (Paris). 1980 Jan-Feb;41(1):55-6.

Abstract

Reduction of hyperprolactinemia by Methysergide (4.4 mg p.o.) and Bromocriptine (2.5 ng p.o.) was studied in 20 patients (7 subjects with pituitary macroadenoma and 13 hyperprolactinemic patients with normal sella turcica). No difference was observed between the effects of the two drugs 4 hours after their administration, with and without respect of the aetiologies of hyperprolactinemia. However the serum prolactin levels were significantly lower 6 hours (n = 11 p = 0,01) and 12 hours (n = 10 p less than 0,01) after Bromocriptine than after methysergide. The difference observed between the two drugs seems to be inherent to their different half-lives.

摘要

对20例患者（7例垂体大腺瘤患者和13例蝶鞍正常的高泌乳素血症患者）进行了研究，观察了麦角新碱（口服4.4毫克）和溴隐亭（口服2.5毫克）降低高泌乳素血症的效果。给药4小时后，无论高泌乳素血症的病因如何，两种药物的效果均未观察到差异。然而，溴隐亭给药后6小时（n = 11，p = 0.01）和12小时（n = 10，p < 0.01）血清泌乳素水平显著低于麦角新碱给药后。两种药物之间观察到的差异似乎与其不同的半衰期有关。