Bruckner N, Katz R A, Hood A F
Arch Dermatol. 1980 Jul;116(7):815-6.
A 78-year-old man had an acute eruption of lesions that clinically resembled seborrheic keratoses. Microscopic examination of the lesions indicated acantholysis and dyskeratosis primarily in the granular layer. The patient's serum contained antibodies to intercellular substance. Direct immunofluorescence microscopy of a lesion demonstrated immunoglobulin deposition in the intercellular areas. Treatment with oral prednisone produced rapid resolution of the lesions. Patients in whom eruptive seborrheic keratoses (Leser-Trélat sign) develop should have histological examination of their lesions to rule out the diagnosis of pemphigus foliaceus.
一名78岁男性突发皮疹，临床表现类似脂溢性角化病。对皮疹进行显微镜检查显示棘层松解和角化不良主要发生在颗粒层。患者血清中含有针对细胞间物质的抗体。对一处皮疹进行直接免疫荧光显微镜检查，发现免疫球蛋白沉积于细胞间区域。口服泼尼松治疗后皮疹迅速消退。出现发疹性脂溢性角化病（Leser-Trélat征）的患者应进行皮疹组织学检查，以排除落叶型天疱疮的诊断。
