McKenzie J A, Dearn J M, Whitten M J
Aust J Biol Sci. 1980 Mar;33(1):85-95.
Populations of L. cuprina from the Bairnsdale, Glenrowan, Hamilton and Torrita areas of Victoria were found to have similar high diazinon resistance status, following near fixation of a single allele at the R1 locus. Pure-breeding resistant strains were derived from each area and used as base populations for a selection program on adults. An approximate doubling of the level of resistance to diazinon was achieved in each strain after eight generations of selection. Relaxation of selection over seven generations showed the response had generated a stable plateau in all but the Torrita selected strain, which regressed towards the resistance level of the original base population. The genetic mechanism associated with the response to selection in each strain was autosomal but unique for each selected strain. Genetic effects directly influenced the resistance phenotype or acted through modification of the major locus. The possible reasons for the uniform-resistance status of the field populations are discussed in terms of the observed selection responses and the likely selection regimes operating in the laboratory and field.
在维多利亚州的拜恩斯代尔、格伦罗文、汉密尔顿和托里塔地区，发现铜绿蝇种群在R1位点的单个等位基因近乎固定后，对二嗪农具有相似的高抗性状态。从每个地区获得了纯合抗性品系，并将其用作成虫选择计划的基础种群。经过八代选择后，每个品系对二嗪农的抗性水平大约提高了一倍。经过七代的选择放松，结果表明，除托里塔选择品系外，所有品系的反应都产生了一个稳定的平台期，托里塔选择品系向原始基础种群的抗性水平回归。每个品系中与选择反应相关的遗传机制是常染色体遗传，但每个选择品系都是独特的。遗传效应直接影响抗性表型或通过修饰主要基因座起作用。根据观察到的选择反应以及实验室和田间可能的选择机制，讨论了田间种群抗性状态一致的可能原因。
