Massari S, Arslan P, Nicolussi A, Colonna R
Biochim Biophys Acta. 1980 Jun 20;599(1):110-7. doi: 10.1016/0005-2736(80)90060-7.
Dipalmitoyl phosphatidylcholine vesicles incubated in the presence of increasing amounts of myristic acid showed a progressive translocation of phospholipid molecules across a dialysis membrane. The rate of phospholipid translocation increased abruptly at a 'critical' value of myristic acid concentrations. The translocation rate of mixed dipalmitoyl phosphatidylcholine/myristic acid vesicles obtained by cosonicating the two components was also dependent on a 'critical' fatty acid concentration. A marked release of K+ and different responses of fluorescent probes to the fatty acid addition were observed at this concentration.
在不断增加肉豆蔻酸的情况下孵育的二棕榈酰磷脂酰胆碱囊泡显示，磷脂分子逐渐穿过透析膜发生易位。在肉豆蔻酸浓度达到“临界”值时，磷脂易位速率突然增加。通过将两种成分进行共超声处理得到的二棕榈酰磷脂酰胆碱/肉豆蔻酸混合囊泡的易位速率也取决于“临界”脂肪酸浓度。在此浓度下观察到钾离子的显著释放以及荧光探针对脂肪酸添加的不同反应。
