负性疏水离子作为正离子的转运介质：载体机制的证据。

Negative hydrophobic ions as transport-mediators for positive ions: evidence for a carrier mechanism.

作者信息

Stark G

出版信息

Biochim Biophys Acta. 1980 Jul 16;600(1):233-7. doi: 10.1016/0005-2736(80)90428-9.

Abstract

The permeability of hydrophobic cations, such as tetraphenylarsonium across biological membranes and artificial lipid membranes is strongly increased in the presence of trace amounts of hydrophobic anions like tetraphenylborate (Liberman, Y.A. and Topaly, V.P. (1969) Biofizika 14, 452--461). Voltage-jump relaxation experiments performed on thin lipid membranes support the idea that the anions, A-, act as carriers for the cations, B+, by the formation of neutral ion pairs, A-B+. Their permeability is not affected by the electric dipole potential, which hinders the movement of free cations, B+.

摘要

在痕量疏水性阴离子（如四苯硼酸盐）存在的情况下，疏水性阳离子（如四苯砷离子）跨生物膜和人工脂质膜的渗透性会显著增加（利伯曼，Y.A.和托帕利，V.P.（1969年）《生物物理学》14卷，452 - 461页）。在薄脂质膜上进行的电压跃变弛豫实验支持这样一种观点，即阴离子A⁻ 通过形成中性离子对A⁻B⁺ 作为阳离子B⁺ 的载体。它们的渗透性不受阻碍游离阳离子B⁺ 移动的电偶极势的影响。