Saran A, Chatterjee C L
Biochim Biophys Acta. 1980 May 30;607(3):490-502. doi: 10.1016/0005-2787(80)90159-8.
PCILO computations ahve been carried out on the conformational properties of 3-deazapyrimidine nucleosides namely: 3-deazauridine and 3-deazacytidine. These nucleoside analogs result as a consequence of the replacement of N(3) by a carbon atom and they become nucleoside antibiotics having cytostatic and antiviral properties. Both C(2')-endo and C(3')-endo sugar geometries have been considered and the results indicate that the conformational preferences of these nucleoside antibiotics are very similar to those of their parent nucleosides and more particularly so in the situations that occur in aqueous solutions. The important biological significance of the results has been discussed.
已对3-脱氮嘧啶核苷即3-脱氮尿苷和3-脱氮胞苷的构象性质进行了PCILO计算。这些核苷类似物是由于氮原子（N(3)）被碳原子取代而产生的，它们成为具有细胞抑制和抗病毒特性的核苷抗生素。同时考虑了C(2')-内型和C(3')-内型糖的几何结构，结果表明这些核苷抗生素的构象偏好与其母体核苷非常相似，尤其是在水溶液中的情况。已讨论了该结果的重要生物学意义。
