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Platelet factor 4 regulates osteoclastic bone resorption in vitro.

作者信息

Horton J E, Harper J, Harper E

出版信息

Biochim Biophys Acta. 1980 Jul 3;630(3):459-62. doi: 10.1016/0304-4165(80)90295-0.

DOI:10.1016/0304-4165(80)90295-0
PMID:7397235
Abstract

Platelet factor 4, which inhibits collagenases derived from both human skin and granulocytic extracts, was found to block reversibly parathyroid hormone-stimulated 45Ca release from fetal rat bone in vitro. The inhibitory property was equally effective in both actively resorbing bones and in bones stimulated to initiate resorption.

摘要

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Platelet factor 4 regulates osteoclastic bone resorption in vitro.
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