血小板因子4的羧基末端肝素结合片段对碱性成纤维细胞生长因子的受体结合仍具有阻断作用。
Carboxyl-terminal heparin-binding fragments of platelet factor 4 retain the blocking effect on the receptor binding of basic fibroblast growth factor.
作者信息
Sato Y, Waki M, Ohno M, Kuwano M, Sakata T
机构信息
Department of Internal Medicine 1, Oita Medical University.
出版信息
Jpn J Cancer Res. 1993 May;84(5):485-8. doi: 10.1111/j.1349-7006.1993.tb00163.x.
Abstract
Platelet factor 4 (PF-4) blocks the binding of basic fibroblast growth factor (bFGF) to its receptor. In the present study, we constructed carboxyl-terminal fragments, which represent the heparin-binding region of the PF-4 molecule, and examined whether these synthetic peptides retain the blocking effects on the receptor binding of bFGF. Synthetic peptides inhibited the receptor binding of bFGF. Furthermore, they inhibited the migration and tube formation of bovine capillary endothelial cells in culture (these phenomena are dependent on endogenous bFGF).
摘要
血小板因子4（PF-4）可阻断碱性成纤维细胞生长因子（bFGF）与其受体的结合。在本研究中，我们构建了代表PF-4分子肝素结合区域的羧基末端片段，并检测这些合成肽是否保留对bFGF受体结合的阻断作用。合成肽抑制了bFGF的受体结合。此外，它们还抑制了培养的牛毛细血管内皮细胞的迁移和管形成（这些现象依赖于内源性bFGF）。
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