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血小板因子4的羧基末端肝素结合片段对碱性成纤维细胞生长因子的受体结合仍具有阻断作用。

Carboxyl-terminal heparin-binding fragments of platelet factor 4 retain the blocking effect on the receptor binding of basic fibroblast growth factor.

作者信息

Sato Y, Waki M, Ohno M, Kuwano M, Sakata T

机构信息

Department of Internal Medicine 1, Oita Medical University.

出版信息

Jpn J Cancer Res. 1993 May;84(5):485-8. doi: 10.1111/j.1349-7006.1993.tb00163.x.

DOI:10.1111/j.1349-7006.1993.tb00163.x
PMID:8320164
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5919175/
Abstract

Platelet factor 4 (PF-4) blocks the binding of basic fibroblast growth factor (bFGF) to its receptor. In the present study, we constructed carboxyl-terminal fragments, which represent the heparin-binding region of the PF-4 molecule, and examined whether these synthetic peptides retain the blocking effects on the receptor binding of bFGF. Synthetic peptides inhibited the receptor binding of bFGF. Furthermore, they inhibited the migration and tube formation of bovine capillary endothelial cells in culture (these phenomena are dependent on endogenous bFGF).

摘要

血小板因子4（PF-4）可阻断碱性成纤维细胞生长因子（bFGF）与其受体的结合。在本研究中，我们构建了代表PF-4分子肝素结合区域的羧基末端片段，并检测这些合成肽是否保留对bFGF受体结合的阻断作用。合成肽抑制了bFGF的受体结合。此外，它们还抑制了培养的牛毛细血管内皮细胞的迁移和管形成（这些现象依赖于内源性bFGF）。

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Carboxyl-terminal heparin-binding fragments of platelet factor 4 retain the blocking effect on the receptor binding of basic fibroblast growth factor.血小板因子4的羧基末端肝素结合片段对碱性成纤维细胞生长因子的受体结合仍具有阻断作用。
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Platelet factor 4 modulates the mitogenic activity of basic fibroblast growth factor.血小板因子4调节碱性成纤维细胞生长因子的促有丝分裂活性。
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本文引用的文献

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Platelet factor 4 regulates osteoclastic bone resorption in vitro.
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Autocrine activities of basic fibroblast growth factor: regulation of endothelial cell movement, plasminogen activator synthesis, and DNA synthesis.碱性成纤维细胞生长因子的自分泌活性：对内皮细胞运动、纤溶酶原激活物合成及DNA合成的调节
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Recent developments in the cell biology of basic fibroblast growth factor.碱性成纤维细胞生长因子细胞生物学的最新进展
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6
Platelet factor 4 blocks the binding of basic fibroblast growth factor to the receptor and inhibits the spontaneous migration of vascular endothelial cells.血小板第4因子可阻断碱性成纤维细胞生长因子与受体的结合，并抑制血管内皮细胞的自发迁移。
Biochem Biophys Res Commun. 1990 Oct 30;172(2):595-600. doi: 10.1016/0006-291x(90)90715-y.
7
Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor.细胞表面的类肝素分子是碱性成纤维细胞生长因子与其高亲和力受体结合所必需的。
Cell. 1991 Feb 22;64(4):841-8. doi: 10.1016/0092-8674(91)90512-w.
8
Autocrinological role of basic fibroblast growth factor on tube formation of vascular endothelial cells in vitro.
Biochem Biophys Res Commun. 1991 Oct 31;180(2):1098-102. doi: 10.1016/s0006-291x(05)81179-9.
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Inhibition of angiogenesis by recombinant human platelet factor-4 and related peptides.重组人血小板因子-4及相关肽对血管生成的抑制作用。
Science. 1990 Jan 5;247(4938):77-9. doi: 10.1126/science.1688470.
10
Platelet factor 4 selectively inhibits binding of TGF-beta 1 to the type I TGF-beta 1 receptor.血小板因子4选择性抑制转化生长因子β1（TGF-β1）与I型TGF-β1受体的结合。
J Cell Biochem. 1991 Sep;47(1):31-42. doi: 10.1002/jcb.240470105.