Warshaw D M, Root D T, Halpern W
Blood Vessels. 1980;17(5):257-70. doi: 10.1159/000158255.
Spontaneously hypertensive (SHR) and normotensive Wistar-Kyoto rats (WKY), 25 weeks of age, were treated for 23 weeks with hydrochlorothiazide, hydralazine, and reserpine added to their drinking water. Cylindrical segments of mesenteric arteries (about 170 micrometers diameter, and 0.7 mm long) were isolated and mounted in a myograph for dimensional and circumferential tension measurements. Treatment of the SHR and WKY decreased systolic blood pressures by 29% and the smooth muscle cell (SMC) content of these vessels by 31%. A linear relation was found between blood pressure and SMC content for all treated and untreated rats. Our results suggest that effect of treatment on the cellular content of the media was sufficient to account entirely for the maintenance of the lowered blood pressure.
25周龄的自发性高血压大鼠（SHR）和血压正常的Wistar-Kyoto大鼠（WKY），在其饮用水中添加氢氯噻嗪、肼屈嗪和利血平进行为期23周的治疗。分离出肠系膜动脉的圆柱形节段（直径约170微米，长0.7毫米），并安装在肌动描记器中进行尺寸和圆周张力测量。对SHR和WKY的治疗使收缩压降低了29%，这些血管的平滑肌细胞（SMC）含量降低了31%。在所有治疗和未治疗的大鼠中，血压与SMC含量之间发现了线性关系。我们的结果表明，治疗对中膜细胞含量的影响足以完全解释血压降低的维持情况。
