Tyroler H A, Heiss G, Schonfeld G, Cooper G, Heyden S, Hames C G
Circulation. 1980 Aug;62(2):249-54. doi: 10.1161/01.cir.62.2.249.
Plasma levels of lipids, lipoprotein-cholesterol and three major apolipoproteins (ApoA-I, A-II and C-II) were studied in 318 black and white males and females randomly sampled in Evans County, Georgia. Black-white differences in lipid and lipoprotein-cholesterol concentrations were observed, with low-density fractions higher in whites and high-density fractions higher in blacks. Plasma levels of ApoA-I but not ApoA-II were higher in blacks than in whites and in females than in males. ApoC-II concentrations were lower in black than in white men and women. Black-white differences in atherogenic lipoprotein fractions were statistically explained (in the sense of association, not necessarily of causal process) by the differences in ApoC-II concentrations between the race groups. Black-white differences in anti etherogenic high-density lipoprotein-cholesterol were greater than statistically predicted by differences in ApoA lipoprotein levels. The findings are indicative of black-white differences in lipoprotein composition.
在佐治亚州埃文斯县随机抽取的318名黑人和白人男性及女性中，研究了血脂、脂蛋白胆固醇和三种主要载脂蛋白（载脂蛋白A-I、A-II和C-II）的血浆水平。观察到黑人和白人在脂质和脂蛋白胆固醇浓度上存在差异，白人的低密度组分较高，而黑人的高密度组分较高。黑人的血浆载脂蛋白A-I水平高于白人，女性高于男性，但载脂蛋白A-II并非如此。黑人的载脂蛋白C-II浓度低于白人男性和女性。种族组间载脂蛋白C-II浓度的差异在统计学上解释了（从关联意义上讲，不一定是因果过程）致动脉粥样硬化脂蛋白组分的黑白差异。抗动脉粥样硬化高密度脂蛋白胆固醇的黑白差异大于根据载脂蛋白A水平差异的统计学预测值。这些发现表明脂蛋白组成存在黑白差异。
