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黑人成年人的脂质和脂蛋白分布。辛辛那提脂质研究诊所普林斯顿学校研究。

Lipid and lipoprotein distributions in black adults. The Cincinnati Lipid Research Clinic's Princeton School Study.

作者信息

Morrison J A, Khoury P, Mellies M, Kelly K, Horvitz R, Glueck C J

出版信息

JAMA. 1981 Mar 6;245(9):939-42.

PMID:7463698
Abstract

To provide population data on levels of plasma cholesterol, triglyceride, and high- and low-density lipoprotein-cholesterol (HDL-C and LDL-C) in black adults, 627 black adults, aged 20 to 59 years, 206 men and 421 women, were studied in the Cincinnati Lipid Research Clinic's Princeton School Study. Comparisons were made with 2,493 white adults, aged 20 to 59 years, 1,111 men and 1,382 women, from the Princeton School Study. Black men had total plasma cholesterol levels that were comparable with those in whites; plasma cholesterol levels were higher in black than white women. Black men had lower levels of plasma triglycerides, higher HDL-C levels, and lower LDL-C levels than white men. Black women not taking exogenous sex steroid hormones had higher total cholesterol and HDL-C levels, and lower triglyceride and LDL-C levels than white women not taking exogenous sex steroid hormones. Black women taking exogenous sex steroid hormones had lower plasma cholesterol and triglyceride levels and slightly higher HDL-C and lower LDL-C levels than white women taking exogenous sex steroid hormones. These differences not only require the use of race-specific lipoprotein distribution tables for characterization of individual subjects, but are consistent with putatively reduced risk for coronary heart disease in blacks when compared with whites.

摘要

为了获取成年黑人血浆胆固醇、甘油三酯以及高密度和低密度脂蛋白胆固醇(HDL-C和LDL-C)水平的人群数据,辛辛那提脂质研究诊所的普林斯顿学校研究对627名年龄在20至59岁之间的成年黑人进行了研究,其中男性206名,女性421名。并与普林斯顿学校研究中的2493名年龄在20至59岁之间的成年白人进行了比较,其中男性1111名,女性1382名。黑人男性的血浆总胆固醇水平与白人相当;黑人女性的血浆胆固醇水平高于白人女性。黑人男性的血浆甘油三酯水平低于白人男性,HDL-C水平高于白人男性,LDL-C水平低于白人男性。未服用外源性性激素的黑人女性比未服用外源性性激素的白人女性总胆固醇和HDL-C水平更高,甘油三酯和LDL-C水平更低。服用外源性性激素的黑人女性比服用外源性性激素的白人女性血浆胆固醇和甘油三酯水平更低,HDL-C水平略高,LDL-C水平更低。这些差异不仅需要使用种族特异性脂蛋白分布表来描述个体受试者的特征,而且与黑人与白人相比冠心病风险可能降低是一致的。

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