Guyton R A, Jacobs M L, Fowler B N, Geffin G A, O'Keefe D D, Daggett W M
Circulation. 1980 Aug;62(2 Pt 2):I26-33.
A new canine model was developed to compare two cardiplegic agents using each heart as its own control. Paired piezoelectric crystals were implanted into the left anterior descending and circumflex regions. The percentage of shortening (systolic shortening/end-diastolic segment length X 100) was assessed in each region on right-heart bypass over a range of cardiac outputs. Durng 100 minutes of ischemic arrest the left anterior descending and circumflex regions were perfused separately every 20 minutes with either cold buffered saline or cold KCl cardioplegia solutions. After recovery, the percentage of shortening after ischemic arrest was determined. The percentage of shortening in the region protected by KCl was unchanged (12.5 +/- 5.0 to 13.0 +/- 4.6%) after arrest, but was markedly decreased in the buffered saline region (11.3 +/- 5.9 to 3.2 +/- 4.9%) (p < 0.001, n = 6). This model should facilitate the comparison of two cardioplegic solutions.
开发了一种新的犬类模型，以每颗心脏自身作为对照来比较两种心脏停搏剂。将成对的压电晶体植入左前降支和回旋支区域。在一系列心输出量下，通过右心旁路在每个区域评估缩短百分比（收缩期缩短/舒张末期节段长度×100）。在100分钟的缺血性停搏期间，左前降支和回旋支区域每20分钟分别用冷缓冲盐水或冷氯化钾心脏停搏液灌注一次。恢复后，测定缺血性停搏后的缩短百分比。氯化钾保护区域的缩短百分比在停搏后未改变（从12.5±5.0%至13.0±4.6%），但在缓冲盐水区域显著降低（从11.3±5.9%至3.2±4.9%）（p<0.001，n=6）。该模型应有助于比较两种心脏停搏液。
