Kiprov D
Cor Vasa. 1980;22(1-2):116-28.
The article presents a review of experimental modelling of hypertension with the purpose helping research on its pathogenetical mechanisms, its characteristic, its therapy and eventual prophylaxy. Both conventional and genetic experimental models of inducing hypertension are discussed. The paper comprises a short description of the methods, their possibilities, the form of human hypertension to which each model corresponds, as well as the most important peculiarities of the alterations which are induced by the corresponding method. Special attention was paid to the most recent models of genetically determined spontaneous hypertension including spontaneously hypertensive rats (SHR-Okamoto-Aoki), the New Zealand strain of genetic hypertension (GH-Smirk), the stroke prone and stroke resistant substrains of SHR (SHRSP and SHRSR), arteriolipoidosis prone SHR (SHRLP), the obese SHR stain, the Milan hypertensive (MHS), Dahl's salt susceptible (s) and salt resistant (R) strains, and Smirk's genetic hypotensive strain of rats.
本文对高血压实验模型进行了综述，目的是帮助研究其发病机制、特征、治疗方法及可能的预防措施。文中讨论了诱导高血压的传统实验模型和基因实验模型。本文简要描述了这些方法、它们的可行性、每种模型所对应的人类高血压类型，以及相应方法所诱导的改变的最重要特点。特别关注了最近的基因决定的自发性高血压模型，包括自发性高血压大鼠（SHR-冈本-青木）、新西兰遗传性高血压品系（GH-斯莫克）、SHR的中风倾向和中风抗性亚品系（SHRSP和SHRSR）、易患动脉粥样硬化的SHR（SHRLP）、肥胖SHR品系、米兰高血压大鼠（MHS）、达尔盐敏感（s）和盐抵抗（R）品系，以及斯莫克的遗传性低血压大鼠品系。
